Case Report – Hijama for Virulent Cellulitis caused by Honey Bee Sting

The following is a case-report which was published at the following link and is reproduced here with the kind permission of the authors:
http://www.researchgate.net/publication/266090581_EFFECT_OF_WET_CUPPING_THERAPY_ON_VIRULENT_CELLULITIS_SECONDARY_TO_HONEY_BEE_STING__A_CASE_REPORT

EFFECT OF WET CUPPING THERAPY ON VIRULENT CELLULITIS SECONDARY TO HONEY BEE STING – A CASE REPORT
Asif Ahmed*, Rafeeq Alam Khan, Amjad Ahsan Ali and M. Ahmed Mesaik
Department of Pharmacology and Therapeutics, Baqai Medical College, Baqai Medical University, Karachi
Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi
Faculty of Medicine, Liaquat National Hospital, Karachi
Dr. Panjwani Center for Molecular Medicine and Drug Research,
International Center for Chemical and Biological Sciences, University of Karachi, Pakistan
Abstract
Cellulitis is clinical condition that is caused by the inflammation of sub-cutaneous tissue.
Conventional treatment of cellulitis is based on the use of antimicrobials. Treatment by Cupping is one of the oldest ways of healing for more than 5000 years; now reemerging in this modern age and is being practice in many countries such as USA, UK, Germany and China.
This is the first reported case in which, twice a healthy subject was stung by honeybee and was effectively treated by cupping therapy. In the first attack of honeybee sting, a virulent cellulitis developed on the ventral surface of the right forearm. The subject was treated with antimicrobials with no response. Later as an adjunctive treatment, cupping therapy was applied at the site of cellulitis with remarkable and immediate clinical recovery. Interestingly, 45 days later, same
individual was again stung by honeybee on the planter surface of the right big toe and on this occasion immediately cupping was applied; that gave quick relief and no inflammation developed. Cupping therapy may be an effective measure in the treatment of honey bee sting induced cellulitis.
Keywords: Cupping therapy, Cellulitis, Honeybee, Inflammation, Complementary and Alternative Medicine
INTRODUCTION
Cellulitis is an inflammation of sub-cutaneous tissue (Ellis 2000; Swartz and Pasternack 2005), that is usually secondary to multiple bacteria’s, such as Staphylococcus and Streptococcus species (Bisno and Stevens 1996; Donahue and Schwartz G 1998; Howe and Jones 2004). Usually the causative organism enters through the broken skin. Usually the cellulitis is diagnosed on clinical basis and treatment is focused on the use of antimicrobials (Ellis 2000; Swartz and Pasternack 2005; Stevens 2005; Moran 2006). Despite following all standard treatment protocols, the reported mortality and morbidity of cellulitis is still high (Carratal et al., 2003).
Treatment by Cupping is one of the oldest ways of healing for more than 5000 years. Presently it is getting re-attention in many parts of the globe such as Asia, America and Europe (Kemper et al., 2000 Sherman et al., 2001; L¨udtkea et al., 2006). Cupping treatment has been successfully used as an efficient method of treatment in wide array of ailments such as arthritis, migraine, anxiety (Hennawy, 2004; Kaleem et al., 2007). By description, cupping therapy is a process of drawing blood from the cutane of the individual by creating a partial vacuum above the scarificated mark (L¨udtkea et al., 2006).
CASE PRESENTATION
Honeybee on the forearm area stung a 38-year-old male. Six hours after the sting, the patient was seen by his family physician. At the site of the sting, mild induration (5 mm), encircled by an erythematic patch was seen. A clinical diagnosis of early Cellulitis was made. The patient was empirically, given an antimicrobial (Lincomycin-oral 600mg/twice a day). In next 6 hours, the lesion was noted to progress and oral Lincomycin was changed to injectable from. Three hours later, flush of erythema was further increased to 5 inches towards the cubital fossa and 1-1/2 inches towards the wrist joint. At this time, it was considered, that probably Lincomycin is not a right choice, so it was replaced by Augmentin 1g (oral) B.D and Metronidazole 500 mg (oral) TID. Over the next 8 hours, despite this treatment the lesion continued to be deepened and spread. The skin of the whole forearm became violently red and hot. Looking at unresponsive behavior of the disease, Ciprofloxacin 500mg TID (oral) was also added in the treatment regimen. From beginning, the patient was also receiving Celecoxibe 100mg BD as an anti-inflammatory agent. Looking at the worsening clinical condition of the patient, he was referred to a senior medical consultant, well experienced in wet cupping therapy. At this point of time, it was decided to apply wet cupping over this aggressive cellulitis. With standard method and sterilization (L¨udtkea et al., 2006; Farhadi et al., 2009); wet cupping was done on the site of maximum inflammation by applying approximately 30 -35 superficial cuts and approximately 7-9 ml of blood (90% clotted and 10% liquid form) was cupped out. An immediate (25-35%) clinical improvement was noted in terms of reduction in all signs of inflammation. After 12 hours, a second cupping was conducted over the same points. Approximately 4-6 ml of blood was taken out from every point. Remarkable clinical recovery was noted and in signs of inflammation; and the patient felt dramatic relief in his over all condition. All cuts of cupping therapy healed completely in the next 4 days without complications. During and after cupping the patient was maintained on Augmentin (1 g BD-oral for 5 days).
Unfortunately, after 45 days, honey bee, again stung the same patient over the planter surface, near the base of the big toe. This time, at the site of the sting, three sessions of cupping therapy were conducted every 12 hours. The ensuing Cellulitis resolved without complications. This time the patient did not receive any medication.
DISCUSSION
Honeybee is a unique insect that produce various products, such as natural honey and royal jelly. One of the natural instincts of honeybee is to sting when annoyed. There are a small number of clinical information available in the text about the honeybee sting. Essentially, in all reports there was severe clinical deterioration with many biochemical abnormalities (derangement in blood coagulation and impairment of different body enzymes such as hepatic aminotranferaces) (Ouyang et al., 1979;
Kini et al., 1994; Franco et al., 1994; Gowlik et al., 2004).

Cellulitis is a commonly occurring clinical disorder. The most suitable method of treating this morbid condition is the judicious use of antimicrobials. Some time the virulence of the affecting microorganism, inadequacy of antimicrobials and the late presentation of the patient in the clinic and finally the presence of any co-morbid condition such as diabetes pose problems in the management of cellulitis.
In the reported case, the affected person was a healthy male, who presented to the clinician at somewhat early phase of his illness and took a plethora of antimicrobials that belonged to different classes of pharmacological agents. The antimicrobial combination used during the treatment have been effective against most of the bacteria’s that can broadly be classified in gram positive, gram negative and anaerobes. The dose of antimicrobials was also noted to be reasonable. Despite the use of reasonable combination, the tempo of the disease was very fast. In this situation, cupping therapy was given to the patient, improved clinical state dramatically at a stage when his clinical status was deteriorating rapidly despite reasonable effort. It can be assumed that either the toxin of the sting or the secondary bacterial infection was very virulent.
Presently the cupping therapy is classified as ‘Complementary and alternative medicine (CAM). The
important base line theory of CAM; is that the internal organs of the corpse illustrate definite relations to definite areas of the body’s exterior recognized as ‘‘reflexuous zones’’. Handling of these reflexuous zones exhibits special effects over the corpus reflected as changes of tissue steadiness and puffiness of tissue volume. Current controlled observational studies on diverse clinical situation such as ischemic heart diseases, vascular disorders, migraine headache, dysmenorrhea, have shown numerically important links that present among diseases and their particular reflexous areas (L¨udtkea et al., 2006).
It can be presumed that during cupping therapy many desired changes would have been taken place in the affected tissues such as elimination of toxins or possibly microorganism that caused the improvement in the clinical condition. Recently Bilal et al. analyzed and compared the Cupping blood and venous blood and found significant difference between two blood samples.Usually at one point of cupping an average of 35-45 superficial cuts are applied. Surprisingly, after cupping the wound, healing was very fast; usually in these types of infected wound, one expects delay in healing. Another noteworthy point is a possible secondary bacteremia on manipulation of an active lesion did not occur. On the first occasion, it can be assumed that the patient was covered with antimicrobials; but fascinatingly this was not the case on the second occasion and the patient directly had the sessions of cupping therapy without antimicrobial cover.
CONCLUSION
Cellulitis is a commonly occurring clinical problem in medical practice. Some times conventional treatment fails to achieve the desired goals. In this situation, application of cupping therapy might be beneficial.
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Memon Institute of Hijama Therapy

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